Sequence and expression of a novel GABAA receptor α subunit
نویسندگان
چکیده
منابع مشابه
Prenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats
Objective(s): Stress during pregnancy is able to bring extensive effects on neurobehavioral development in offspring. The GABAergic system plays a pivotal role in neuronal excitability, which can be affected by prenatal stress (PS). This study aimed to evaluate impact of the PS on γ2 subunit of gamma-aminobutyric acid A (GABAA) receptor gene expression in the hippocamp...
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15 صفحه اولFunctional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain.
Two alpha subunits of the GABAA receptor in rat brain have been identified by molecular cloning. The deduced polypeptide sequences share major characteristics with other chemically gated ion channel proteins. One polypeptide represents the rat homologue of the alpha 3 subunit previously cloned from bovine brain, while the other polypeptide is a yet known subunit, termed alpha 5. When coexpresse...
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Profound evidence indicates that GABAA receptors are important in the control of physiological response to stress and anxiety. The a subunit type composition contributes significantly to the functional characterization of the GABAA receptors. The a2, a3, a5 subunits are predominately expressed in the brain during embryonic and early postnatal periods of normal rats, whilst a1 are most prominent...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1989
ISSN: 0014-5793
DOI: 10.1016/0014-5793(89)81630-8